Piperine, an alkaloid from Pepper species is used as bioenhancer. The present study investigated the influence of co-administration of piperine on pharmacokinetic profile of Gatifloxacin in Broiler birds. Gatifloxacin (GFX) is a fourth generation, 8-methoxy fluoroquinolone. The pharmacokinetic profile of gatifloxacin (10 mg/kg body weight) along with piperine coadministration (15 mg/kg) via single dose oral administration in broiler birds shown half life (t 1/2 β), Maximum drug concentration (Cmax) and AUC of 4.1 ± 0.092 hour, 2.14 ± 0.02 µg/ml and 17.58 ± 0.17 µg.h/ml respectively, which is found significantly higher than half life (t 1/2 β), Maximum drug concentration (Cmax) and AUC of 3.81 ± 0.07 hour, 1.74 ± 0.024 µg/ml and 15.24 ± 0.23 µg.h/ml respectively obtain after single oral administration of gatifloxacin (10 mg/kg body weight) alone. This study reveals that piperine has significant effect on the pharmacokinetics of the Gatifloxacin. There is significant enhancement of bioavailability (F) in piperine treated group (81.95 ± 1.56 %) compared to gatifloxacin alone treated group (72.96 ± 1.10 %). The results obtained are the combined effect of piperine on the absorption kinetics and the inhibition of the metabolism of Gatifloxacin.
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